TITRATION
Flexible, once-daily dosing for XCOPRI is titrated at 2-week intervals1
XCOPRI can be prescribed as monotherapy or adjunctive therapy1
WEEKS 1-2
12.5 mg
once daily

WEEKS 3-4
25 mg
once daily

WEEKS 5-6
50 mg
once daily

WEEKS 7-8
100 mg
once daily

WEEKS 9-10
150 mg
once daily

WEEK 11 &
THEREAFTER
200 mg
once daily
(recommended
maintenance dosage)

Not actual sizes.
Maximum dosage: Dosage may be increased above 200 mg/day by increments of 50 mg/day every 2 weeks to a maximum of 400 mg/day.
Patients with mild or moderate hepatic impairment: 200 mg/day is the maximum dosage. XCOPRI is not recommended for use in patients with severe hepatic impairment.
See Prescribing Information for additional Dosage and Administration instructions.
GETTING STARTED
Prescribing: From start to maintenance1
Below is an example* of a titration schedule for prescribing XCOPRI. After you have titrated up to find the right maintenance dosage, maintenance blister packs and bottles are available.




MAINTENANCE DOSING
Flexible, once-daily dosing—from start to maintenance
XCOPRI Titration Blister Packs
Designed to simplify the titration schedule of XCOPRI. At-a-glance instructions have been included to assist you and your patients as XCOPRI dosages are increased over time.1

12.5 mg / 25 mg (28-day supply)

50 mg / 100 mg (28-day supply)

150 mg / 200 mg (28-day supply)
XCOPRI Maintenance Blister Packs and Bottles
Designed to give you the flexibility to find the dosage that is right for your individual patients.1

Maintenance blister
packs available:
• 250 mg [28-day supply]
• 350 mg [28-day supply]

Maintenance bottles available:
• 50 mg (30-count bottle)
• 100 mg (30-count bottle)
• 150 mg (30-count bottle)
• 200 mg (30-count bottle)
MANAGING ADJUNCTIVE THERAPY
Managing the adjunctive use of XCOPRI
Managing the Adjunctive Use of XCOPRI
In this interactive video, watch as Lawrence Seiden, MD, and Barry Gidal, PharmD, discuss anti-seizure medication (ASM) dosing considerations to be aware of when adding XCOPRI to a patient’s treatment regimen. Discover essential information regarding the optimization of XCOPRI’s efficacy, plus potential ways to minimize side effects—and be sure to bookmark for reference.
(anti-seizure medication)
XCOPRI makes the concentration of some drugs go up. Consider decreasing the dosage of clobazam, phenytoin, and phenobarbital early in XCORPI titration.1,2
If a patient experiences common adverse events, consider decreasing the dosage of other ASMs.1,2*
Find more information for prescribing XCOPRI with concomitant medications