TITRATION
Flexible, once-daily dosing options to take patients through their treatment journey1
XCOPRI® (CENOBAMATE TABLETS) CV IS TITRATED AT 2-WEEK INTERVALS1
WEEKS 1-2
12.5 mg
once daily

WEEKS 3-4
25 mg
once daily

WEEKS 5-6
50 mg
once daily

WEEKS 7-8
100 mg
once daily

WEEKS 9-10
150 mg
once daily

WEEK 11 &
THEREAFTER
200 mg
once daily
(recommended
maintenance dosage)

Not actual sizes.
XCOPRI can be prescribed as monotherapy or adjunctive therapy1
Maximum dosage: If needed based on clinical response and tolerability, dosage may be increased above 200 mg/day by increments of 50 mg/day every 2 weeks to a maximum of 400 mg/day.1
For patients with mild or moderate hepatic impairment, the maximum recommended dosage is 200 mg once daily. XCOPRI is not recommended for use in patients with severe hepatic impairment.1
See Prescribing Information for additional Dosage and Administration instructions.
In an open-label study, when XCOPRI was titrated at 2-week intervals, there were no reported cases of drug reaction with eosinophilia and systemic symptoms (DRESS). This finding does not establish that the risk of DRESS is prevented by a slower titration; however, XCOPRI should be initiated at 12.5 mg once daily and titrated every 2 weeks.1
MAINTENANCE
Raise your expectations to the possibility of ZERO seizures1
285,482 PRESCRIPTIONS HAVE BEEN WRITTEN TO DATE FOR XCOPRI2*
Get your patients started today!
XCOPRI Titration Blister Packs
Designed to simplify the titration schedule of XCOPRI. At-a-glance
instructions have been included to assist you and your patients as
XCOPRI doses are increased over time.1



XCOPRI Maintenance Blister Packs and Bottles
Designed to give you the flexibility to find the XCOPRI dosage
that is right for your individual patients.1

Maintenance blister
packs available:
• 250 mg [28-day supply]
• 350 mg [28-day supply]

Maintenance bottles available:
• 50 mg (30-count bottle)
• 100 mg (30-count bottle)
• 150 mg (30-count bottle)
• 200 mg (30-count bottle)
How to Prescribe from Titration Phase to Maintenance Dosing
Below is an example† of a titration schedule for prescribing XCOPRI. After you have titrated up to find the right maintenance dose, maintenance blister packs and bottles are available.1



